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Outcome of idiopathic membranoproliferative glomerulonephritis in children. Arbeitsgemeinschaft Pädiatrische Nephrologie

The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 p...

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Main Authors: Schwertz, Rainer (Author) , de Jong, R. (Author) , Gretz, Norbert (Author) , Kirschfink, Michael (Author) , Anders, D. (Author) , Schärer, Karl (Author)
Format: Article (Journal)
Language:English
Published: 1996
In: Acta paediatrica
Year: 1996, Volume: 85, Issue: 3, Pages: 308-312
ISSN:1651-2227
DOI:10.1111/j.1651-2227.1996.tb14022.x
Online Access:Verlag, Volltext: https://doi.org/10.1111/j.1651-2227.1996.tb14022.x
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1651-2227.1996.tb14022.x
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Author Notes:R. Schwertz, R. de Jong, N. Gretz, M. Kirschfink, D. Anders, K. Schärer and Arbeitsgemeinschaft Pädiatrische Nephrologie
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Summary:The aim of this multicentre study was to analyse the long-term outcome of idiopathic membranoproliferative glomerulonephritis (MPGN) according to histological type and to the presence of C3 nephritic factor. Fifty patients aged 2-14 years at the onset of the study were followed over 2-20 years; 26 patients had MPGN type I, 17 had type II and 7 had type III. Treatment was variable. At the last observation, 30 patients had reached terminal and four pre-terminal renal failure. The median survival probability until renal death was 15.3, 8.7 and 15.9 years for disease types I, II and III respectively (difference between MPGN types I + III versus type II: p = 0.013). The presence of an initial nephrotic syndrome was associated with a more rapid progression (p = 0.018). C3 nephritic factor was of no prognostic value. We conclude that the outcome of MPGN mainly depends on the histological type observed.
Item Description:Gesehen am 16.06.2021
Physical Description:Online Resource
ISSN:1651-2227
DOI:10.1111/j.1651-2227.1996.tb14022.x

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