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HBV-infection rate and long-term outcome after liver-transplantation of anti-HBc-positive liver-grafts to HBV-naïve recipients: a retrospective study

Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipien...

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Main Authors: Hornuß, Daniel (Author) , Rudi, Anna (Author) , Koerner, Lucas (Author) , Mohr, Isabelle (Author) , Merle, Uta (Author) , Wehling, Cyrill (Author) , Rupp, Christian (Author) , Dill, Michael T. (Author) , Golriz, Mohammad (Author) , Schnitzler, Paul (Author) , Brenner, Thorsten (Author) , Mehrabi, Arianeb (Author) , Weiss, Karl Heinz (Author) , Mieth, Markus (Author)
Format: Article (Journal)
Language:English
Published: 16 March 2021
In: Clinics and research in hepatology and gastroenterology
Year: 2021, Volume: 45, Issue: 2, Pages: 1-9
ISSN:2210-741X
DOI:10.1016/j.clinre.2020.07.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clinre.2020.07.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2210740120301911
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Author Notes:Daniel Hornuss, Anna Rudi, Lucas Koerner, Isabelle Mohr, Uta Merle, Cyrill Wehling, Christian Rupp, Michael T. Dill, Mohammad Golriz, Paul Schnitzler, Thorsten Brenner, Arianeb Mehrabi, Karl Heinz Weiss, Markus Mieth
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Summary:Background - Anti-HBc only positive liver grafts may be suitable for HBV-naive recipients insofar as an appropriate infection prophylaxis is performed. Therefore, we investigated the effect of prophylactic regimens on HBV infection prevention and long-term outcome of anti-HBc-positive graft recipients. - Patients and methods - This retrospective monocenter study consisted of a cohort of 1912 patients who underwent deceased donor liver transplantation at our transplant center between June 1987 and July 2019. 81 HBV-naïve patients after reception of an anti-HBc-positive liver-graft and consecutive HBV prophylaxis were selected for further examination. HBV infection rate and host- and graft-survival rates were compared to a matched control group consisting of 162 HBV-naïve patients after reception of anti-HBc-negative grafts. Pharmaceutical HBV prophylaxis included: only HBIG, only NUCs, or combined HBIG and NUCs. - Results - Compared to control cases of HBV-naïve anti-HBc-negative graft recipients, no differences in host- and graft-survival rate were determined.13 of 81 anti-HBc-positive graft recipients (16%) developed HBV-infection after liver transplantation. No patient suffered from HBV infection after receiving modern NUCs. Survival analysis showed no statistical differences between patients with and without infection concerning host- and graft-survival. - Conclusion - Especially in times of organ shortage, anti-HBc-positive liver grafts may be useful for liver transplantation in HBV-naïve recipients. Efficient prophylactic regimens can prevent HBV-infection.
Item Description:Im Titel steht ein Trema über dem "i" bei naïve
Gesehen am 16.06.2021
Physical Description:Online Resource
ISSN:2210-741X
DOI:10.1016/j.clinre.2020.07.003

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