Buchumschlag

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant gen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schijven, Dick (VerfasserIn) , Stevelink, Remi (VerfasserIn) , McCormack, Mark (VerfasserIn) , van Rheenen, Wouter (VerfasserIn) , Luykx, Jurjen J. (VerfasserIn) , Koeleman, Bobby P. C. (VerfasserIn) , Veldink, Jan H. (VerfasserIn) , Weishaupt, Jochen H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 April 2020
In: Neurobiology of aging
Year: 2020, Jahrgang: 92, Pages: 153.e1-153.e5
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2020.04.011
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurobiolaging.2020.04.011
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197458020301305
Volltext
Verfasserangaben:Dick Schijven, Remi Stevelink, Mark McCormack, Wouter van Rheenen, Jurjen J. Luykx, Bobby P.C. Koeleman, Jan H. Veldink, on behalf of the Project MinE ALS GWAS Consortium International League Against Epilepsy Consortium on Complex Epilepsies
Beschreibung
Zusammenfassung:Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.
Beschreibung:Project MinE ALS GWAS consortium members: Wouter van Rheenen, Jochen H. Weishaupt [und viele weitere]
Gesehen am 16.06.2021
Beschreibung:Online Resource
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2020.04.011

Ähnliche Einträge