Cover Image

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant gen...

Full description

Saved in:
Bibliographic Details
Main Authors: Schijven, Dick (Author) , Stevelink, Remi (Author) , McCormack, Mark (Author) , van Rheenen, Wouter (Author) , Luykx, Jurjen J. (Author) , Koeleman, Bobby P. C. (Author) , Veldink, Jan H. (Author) , Weishaupt, Jochen H. (Author)
Format: Article (Journal)
Language:English
Published: 18 April 2020
In: Neurobiology of aging
Year: 2020, Volume: 92, Pages: 153.e1-153.e5
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2020.04.011
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neurobiolaging.2020.04.011
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197458020301305
Get full text
Author Notes:Dick Schijven, Remi Stevelink, Mark McCormack, Wouter van Rheenen, Jurjen J. Luykx, Bobby P.C. Koeleman, Jan H. Veldink, on behalf of the Project MinE ALS GWAS Consortium International League Against Epilepsy Consortium on Complex Epilepsies
Description
Summary:Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.
Item Description:Project MinE ALS GWAS consortium members: Wouter van Rheenen, Jochen H. Weishaupt [und viele weitere]
Gesehen am 16.06.2021
Physical Description:Online Resource
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2020.04.011

Similar Items