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Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer: overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

In breast cancer, the role of epigenetic alterations including modifications of the acetylation status of histones in carcinogenesis has been an important research focus during the last years. An increased deacetylation of histones leads to increased cell proliferation, cell migration, angiogenesis...

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Main Authors: Pfitzner, Berit Maria (Author) , Jana, Lisa (Author) , Kasajima, Atsuko (Author) , Lehmann, Annika (Author) , Prinzler, Judith (Author) , Budczies, Jan (Author) , Winzer, Klaus-Jürgen (Author) , Dietel, Manfred (Author) , Weichert, Wilko (Author) , Denkert, Carsten (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2013
In: BMC cancer
Year: 2013, Volume: 13, Pages: 1-8
ISSN:1471-2407
DOI:10.1186/1471-2407-13-215
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-13-215
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Author Notes:Berit Maria Müller, Lisa Jana, Atsuko Kasajima, Annika Lehmann, Judith Prinzler, Jan Budczies, Klaus-Jürgen Winzer, Manfred Dietel, Wilko Weichert and Carsten Denkert
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Summary:In breast cancer, the role of epigenetic alterations including modifications of the acetylation status of histones in carcinogenesis has been an important research focus during the last years. An increased deacetylation of histones leads to increased cell proliferation, cell migration, angiogenesis and invasion. Class 1 histone deacetylases (HDAC) seem to be most important during carcinogenesis.
Item Description:Gesehen am 22.06.2021
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-13-215

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