Role of synaptophysin, chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

Synaptophysin, chromogranin and CD56 are recommended markers to identify pulmonary tumors with neuroendocrine differentiation. Whether the expression of these markers in pulmonary adenocarcinoma and pulmonary squamous cell carcinoma is a prognostic factor has been a matter of debate. Therefore, we i...

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Hauptverfasser: Kriegsmann, Katharina (VerfasserIn) , Zgorzelski, Christiane (VerfasserIn) , Muley, Thomas (VerfasserIn) , Christopoulos, Petros (VerfasserIn) , Thomas, Michael (VerfasserIn) , Winter, Hauke (VerfasserIn) , Eichhorn, Martin E. (VerfasserIn) , Eichhorn, Florian (VerfasserIn) , Winterfeld, Moritz von (VerfasserIn) , Herpel, Esther (VerfasserIn) , Goeppert, Benjamin (VerfasserIn) , Stenzinger, Albrecht (VerfasserIn) , Herth, Felix (VerfasserIn) , Warth, Arne (VerfasserIn) , Kriegsmann, Mark (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 May 2021
In: BMC cancer
Year: 2021, Jahrgang: 21, Pages: 1-9
ISSN:1471-2407
DOI:10.1186/s12885-021-08140-9
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-021-08140-9
Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08140-9
Volltext
Verfasserangaben:Katharina Kriegsmann, Christiane Zgorzelski, Thomas Muley, Petros Christopoulos, Michael Thomas, Hauke Winter, Martin Eichhorn, Florian Eichhorn, Moritz von Winterfeld, Esther Herpel, Benjamin Goeppert, Albrecht Stenzinger, Felix J.F. Herth, Arne Warth and Mark Kriegsmann
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Zusammenfassung:Synaptophysin, chromogranin and CD56 are recommended markers to identify pulmonary tumors with neuroendocrine differentiation. Whether the expression of these markers in pulmonary adenocarcinoma and pulmonary squamous cell carcinoma is a prognostic factor has been a matter of debate. Therefore, we investigated retrospectively a large cohort to expand the data on the role of synaptophysin, chromogranin and CD56 in non-small cell lung cancer lacking morphological features of neuroendocrine differentiation.
Beschreibung:Gesehen am 24.06.2021
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-021-08140-9