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The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra

The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the p...

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Main Authors: Ziegler, Bérénice (Author) , Yiallouros, Irene (Author) , Trageser, Benjamin (Author) , Kumar, Sumit (Author) , Mercker, Moritz (Author) , Kling, Svenja (Author) , Fath, Maike (Author) , Warnken, Uwe (Author) , Schnölzer, Martina (Author) , Holstein, Thomas W. (Author) , Hartl, Markus (Author) , Marciniak-Czochra, Anna (Author) , Stetefeld, Jörg (Author) , Stöcker, Walter (Author) , Özbek, Suat (Author)
Format: Article (Journal)
Language:English
Published: 09 June 2021
In: BMC biology
Year: 2021, Volume: 19, Pages: 1-22
ISSN:1741-7007
DOI:10.1186/s12915-021-01046-9
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12915-021-01046-9
Verlag, kostenfrei, Volltext: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01046-9
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Author Notes:Berenice Ziegler, Irene Yiallouros, Benjamin Trageser, Sumit Kumar, Moritz Mercker, Svenja Kling, Maike Fath, Uwe Warnken, Martina Schnölzer, Thomas W. Holstein, Markus Hartl, Anna Marciniak-Czochra, Jörg Stetefeld, Walter Stöcker and Suat Özbek
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Summary:The Hydra head organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood. Here we report a proteomic analysis of Hydra head tissue leading to the identification of an astacin family proteinase as a Wnt processing factor.
Item Description:Gesehen am 25.06.2021
Physical Description:Online Resource
ISSN:1741-7007
DOI:10.1186/s12915-021-01046-9

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