Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays
Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 10, 2013
|
| In: |
Nano letters
Year: 2013, Volume: 13, Issue: 11, Pages: 5090-5097 |
| ISSN: | 1530-6992 |
| DOI: | 10.1021/nl4022623 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl4022623
|
| Author Notes: | Jovana Matic, Janosch Deeg, Alexander Scheffold, Itamar Goldstein, and Joachim P. Spatz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1761308688 | ||
| 003 | DE-627 | ||
| 005 | 20230426153119.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210625s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/nl4022623 |2 doi | |
| 035 | |a (DE-627)1761308688 | ||
| 035 | |a (DE-599)KXP1761308688 | ||
| 035 | |a (OCoLC)1341417454 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Matić, Jovana |e VerfasserIn |0 (DE-588)1205922784 |0 (DE-627)1691766143 |4 aut | |
| 245 | 1 | 0 | |a Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays |c Jovana Matic, Janosch Deeg, Alexander Scheffold, Itamar Goldstein, and Joachim P. Spatz |
| 264 | 1 | |c October 10, 2013 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.06.2021 | ||
| 520 | |a Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with site-directed protein immobilization techniques represent a novel T cell stimulatory platform that allows tight control over ligand orientation and surface density. Here, we show that activation of primary human CD4+ T cells, defined by CD69 upregulation, IL-2 production and cell proliferation, correlates with aCD3 density on nanoarrays. Immobilization of aCD3 through nanopatterning had two effects: cell activation was significantly higher on these surfaces than on aCD3-coated plastics and allowed unprecedented fine-tuning of T cell response. | ||
| 700 | 1 | |a Deeg, Janosch A. |e VerfasserIn |0 (DE-588)1046964615 |0 (DE-627)777365782 |0 (DE-576)400281694 |4 aut | |
| 700 | 1 | |a Scheffold, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goldstein, Itamar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spatz, Joachim P. |d 1969- |e VerfasserIn |0 (DE-588)122582675 |0 (DE-627)08203124X |0 (DE-576)173014771 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nano letters |d Washington, DC : ACS Publ., 2001 |g 13(2013), 11, Seite 5090-5097 |h Online-Ressource |w (DE-627)330078771 |w (DE-600)2048866-X |w (DE-576)094479208 |x 1530-6992 |7 nnas |a Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays |
| 773 | 1 | 8 | |g volume:13 |g year:2013 |g number:11 |g pages:5090-5097 |g extent:8 |a Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays |
| 856 | 4 | 0 | |u https://doi.org/10.1021/nl4022623 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210625 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 122582675 |a Spatz, Joachim P. |m 122582675:Spatz, Joachim P. |d 120000 |d 120300 |e 120000PS122582675 |e 120300PS122582675 |k 0/120000/ |k 1/120000/120300/ |p 5 |y j | ||
| 999 | |a KXP-PPN1761308688 |e 3941420518 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"October 10, 2013","dateIssuedKey":"2013"}],"language":["eng"],"note":["Gesehen am 25.06.2021"],"physDesc":[{"extent":"8 S."}],"relHost":[{"language":["eng"],"disp":"Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarraysNano letters","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 22.03.23"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"American Chemical Society","role":"isb"}],"origin":[{"dateIssuedDisp":"2001-","publisher":"ACS Publ.","publisherPlace":"Washington, DC","dateIssuedKey":"2001"}],"titleAlt":[{"title":"Nanoletters"}],"title":[{"subtitle":"a journal dedicated to nanoscience and nanotechnology","title":"Nano letters","title_sort":"Nano letters"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"volume":"13","text":"13(2013), 11, Seite 5090-5097","extent":"8","issue":"11","year":"2013","pages":"5090-5097"},"name":{"displayForm":["publ. by the American Chemical Society"]},"pubHistory":["1.2001 -"],"id":{"zdb":["2048866-X"],"eki":["330078771"],"issn":["1530-6992"]},"recId":"330078771"}],"name":{"displayForm":["Jovana Matic, Janosch Deeg, Alexander Scheffold, Itamar Goldstein, and Joachim P. Spatz"]},"id":{"doi":["10.1021/nl4022623"],"eki":["1761308688"]},"recId":"1761308688","title":[{"title":"Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays","title_sort":"Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Jovana","display":"Matić, Jovana","family":"Matić"},{"given":"Janosch A.","roleDisplay":"VerfasserIn","display":"Deeg, Janosch A.","family":"Deeg","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Alexander","display":"Scheffold, Alexander","family":"Scheffold"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Goldstein, Itamar","given":"Itamar","family":"Goldstein"},{"display":"Spatz, Joachim P.","roleDisplay":"VerfasserIn","given":"Joachim P.","family":"Spatz","role":"aut"}]} | ||
| SRT | |a MATICJOVANFINETUNING1020 | ||