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α-lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria

In the present cross-sectional study, the influence of α-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(α-tocopherol/cholesterol), was exami...

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Main Authors: Borcea, Valentin (Author) , Nourooz-Zadeh, Jaffar (Author) , Wolff, Simon P (Author) , Klevesath, Martina (Author) , Hofmann Bowman, Marion (Author) , Urich, Heinz (Author) , Wahl, Peter (Author) , Ziegler, Reinhard (Author) , Tritschler, Hans (Author) , Halliwell, Barry (Author) , Nawroth, Peter Paul (Author)
Format: Article (Journal)
Language:English
Published: 1 July 1999
In: Free radical biology and medicine
Year: 1999, Volume: 26, Issue: 11, Pages: 1495-1500
ISSN:1873-4596
DOI:10.1016/S0891-5849(99)00011-8
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0891-5849(99)00011-8
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0891584999000118
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Author Notes:Valentin Borcea, Jaffar Nourooz-Zadeh, Simon P. Wolff, Martina Klevesath, Marion Hofmann, Heinz Urich, Peter Wahl, Reinhard Ziegler, Hans Tritschler, Barry Halliwell, and Peter P. Nawroth
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Summary:In the present cross-sectional study, the influence of α-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(α-tocopherol/cholesterol), was examined in 107 patients with diabetes mellitus. Patients receiving α-lipoic acid (600 mg/day for > 3 months) had significant lower ROOHs and a lower ROOH/(α-tocopherol/cholesterol) ratio than those without α-lipoic acid treatment [ROOH: 4.76 ± 2.49 vs. 7.16 ± 3.22 μmol/l; p < .0001] and [ROOH/(α-tocopherol/cholesterol): 1.37 ± 0.72 vs. 2.16 ± 1.17; p < 0.0001]. In addition, the influence of glycemic control and albuminuria on ROOHs and on the ratio of ROOH/(α-tocopherol/cholesterol) was examined in the presence and absence of α-lipoic acid treatment. Patients were subdivided into three groups based on (1) their HbA1 levels (<7.5, 7.5-9.5, and >9.5%) and (2) their urinary albumin concentrations (<20, 20-200, and >200 mg/l). Neither poor glycemic control, nor the presence of micro- or macroalbuminuria prevented the antioxidant effect of α-lipoic acid. Using stepwise multiple regression analysis, α-lipoic acid was found to be the only factor significantly predicting low ROOHs and a low ratio of ROOH/(α-tocopherol/ cholesterol). These data provide evidence that treatment with α-lipoic acid improves significantly the imbalance between increased oxidative stress and depleted antioxidant defence even in patients with poor glycemic control and albuminuria.
Item Description:Im PDF wird in den Erscheinungsdaten fälschlicherweise Vol. 22 angegeben
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Physical Description:Online Resource
ISSN:1873-4596
DOI:10.1016/S0891-5849(99)00011-8

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