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Feasibility of 6-month maintenance cetuximab after adjuvant concurrent chemoradiation plus cetuximab in squamous cell carcinoma of the head and neck

Close resection margins < 5 mm (CM) or extra capsular extent at the lymph nodes (ECE) impair the prognosis of patients with squamous cell cancer of the head and neck (SCCHN) scheduled for adjuvant radiochemotherapy. We conducted a multicenter phase II study to investigate toxicity and efficacy of...

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Main Authors: Matuschek, Christiane (Author) , Bölke, E. (Author) , Belka, C. (Author) , Ganswindt, U. (Author) , Henke, M. (Author) , Stegmaier, P. (Author) , Bamberg, M. (Author) , Welz, S. (Author) , Debus, Jürgen (Author) , Gioules, Alexandros (Author) , Voigt, A. (Author) , Volk, G. (Author) , Ohmann, C. (Author) , Wiegel, T. (Author) , Budach, V. (Author) , Stuschke, M. (Author) , Schipper, J. (Author) , Gerber, P.A. (Author) , Budach, W. (Author)
Format: Article (Journal)
Language:English
Published: 5 July 2013
In: Strahlentherapie und Onkologie
Year: 2013, Volume: 189, Issue: 8, Pages: 625-631
ISSN:1439-099X
DOI:10.1007/s00066-013-0378-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00066-013-0378-2
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Author Notes:C. Matuschek, E. Bölke, C. Belka, U. Ganswindt, M. Henke, P. Stegmaier, M. Bamberg, S. Welz, J. Debus, A. Gioules, A. Voigt, G. Volk, C. Ohmann, T. Wiegel, V. Budach, M. Stuschke, J. Schipper, P.A. Gerber, W. Budach
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Summary:Close resection margins < 5 mm (CM) or extra capsular extent at the lymph nodes (ECE) impair the prognosis of patients with squamous cell cancer of the head and neck (SCCHN) scheduled for adjuvant radiochemotherapy. We conducted a multicenter phase II study to investigate toxicity and efficacy of additional cetuximab administered concomitantly and as maintenance for the duration of 6 months following adjuvant radiochemotherapy., Ppreliminary results on feasibility and acute toxicity on skin and mucosa are presented in this article.
Item Description:Gesehen am 29.06.2021
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-013-0378-2

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