Cover Image

Genomic variation landscape of the human gut microbiome

Whereas large-scale efforts have rapidly advanced the understanding and practical impact of human genomic variation, the practical impact of variation is largely unexplored in the human microbiome. We therefore developed a framework for metagenomic variation analysis and applied it to 252 faecal met...

Full description

Saved in:
Bibliographic Details
Main Authors: Schloißnig, Siegfried (Author) , Arumugam, Manimozhiyan (Author) , Sunagawa, Shinichi (Author) , Mitreva, Makedonka (Author) , Tap, Julien (Author) , Zhu, Ana (Author) , Waller, Alison (Author) , Mende, Daniel R. (Author) , Kultima, Jens Roat (Author) , Martin, John (Author) , Kota, Karthik (Author) , Sunyaev, Shamil R. (Author) , Weinstock, George M. (Author) , Bork, Peer (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Nature
Year: 2013, Volume: 493, Issue: 7430, Pages: 45-50
ISSN:1476-4687
DOI:10.1038/nature11711
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature11711
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature11711
Get full text
Author Notes:Siegfried Schloissnig, Manimozhiyan Arumugam, Shinichi Sunagawa, Makedonka Mitreva, Julien Tap, Ana Zhu, Alison Waller, Daniel R. Mende, Jens Roat Kultima, John Martin, Karthik Kota, Shamil R. Sunyaev, George M. Weinstock & Peer Bork
Description
Summary:Whereas large-scale efforts have rapidly advanced the understanding and practical impact of human genomic variation, the practical impact of variation is largely unexplored in the human microbiome. We therefore developed a framework for metagenomic variation analysis and applied it to 252 faecal metagenomes of 207 individuals from Europe and North America. Using 7.4 billion reads aligned to 101 reference species, we detected 10.3 million single nucleotide polymorphisms (SNPs), 107,991 short insertions/deletions, and 1,051 structural variants. The average ratio of non-synonymous to synonymous polymorphism rates of 0.11 was more variable between gut microbial species than across human hosts. Subjects sampled at varying time intervals exhibited individuality and temporal stability of SNP variation patterns, despite considerable composition changes of their gut microbiota. This indicates that individual-specific strains are not easily replaced and that an individual might have a unique metagenomic genotype, which may be exploitable for personalized diet or drug intake.
Item Description:Published online 5 December 2012
Gesehen am 01.07.2021
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature11711

Similar Items