Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury

Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies have shown protective effects of conditioned medium (CM) from bone marrow-derived mesenchymal...

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Main Authors: Korkmaz-İçöz, Sevil (Author) , Zhou, Pengyu (Author) , Guo, Yuxing (Author) , Loganathan, Sivakkanan (Author) , Brlecic, Paige (Author) , Radovits, Tamás (Author) , Sayour, Alex Ali (Author) , Ruppert, Mihály (Author) , Veres, Gábor (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author)
Format: Article (Journal)
Language:English
Published: 24 February 2021
In: Stem cell research & therapy
Year: 2021, Volume: 12, Pages: 1-13
ISSN:1757-6512
DOI:10.1186/s13287-021-02166-3
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13287-021-02166-3
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905634
Resolving-System, kostenfrei: https://dx.doi.org/10.1186/s13287-021-02166-3
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Author Notes:Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck, Gábor Szabó
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Summary:Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies have shown protective effects of conditioned medium (CM) from bone marrow-derived mesenchymal stem cells (MSCs) against IR injury. We hypothesized that physiological saline-supplemented CM protects BD rats’ vascular grafts from IR injury.
Item Description:Gesehen am 13.07.2021
Physical Description:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-021-02166-3