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Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury

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Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies have shown protective effects of conditioned medium (CM) from bone marrow-derived mesenchymal...

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Hauptverfasser: Korkmaz-İçöz, Sevil (VerfasserIn) , Zhou, Pengyu (VerfasserIn) , Guo, Yuxing (VerfasserIn) , Loganathan, Sivakkanan (VerfasserIn) , Brlecic, Paige (VerfasserIn) , Radovits, Tamás (VerfasserIn) , Sayour, Alex Ali (VerfasserIn) , Ruppert, Mihály (VerfasserIn) , Veres, Gábor (VerfasserIn) , Karck, Matthias (VerfasserIn) , Szabó, Gábor (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 24 February 2021
In: Stem cell research & therapy
Year: 2021, Jahrgang: 12, Pages: 1-13
ISSN:1757-6512
DOI:10.1186/s13287-021-02166-3
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13287-021-02166-3
Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905634
Resolving-System, kostenfrei: https://dx.doi.org/10.1186/s13287-021-02166-3
Volltext
Verfasserangaben:Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck, Gábor Szabó
Beschreibung
Zusammenfassung:Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies have shown protective effects of conditioned medium (CM) from bone marrow-derived mesenchymal stem cells (MSCs) against IR injury. We hypothesized that physiological saline-supplemented CM protects BD rats’ vascular grafts from IR injury.
Beschreibung:Gesehen am 13.07.2021
Beschreibung:Online Resource
ISSN:1757-6512
DOI:10.1186/s13287-021-02166-3

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