TRPM4 keeps up the pace
The study by Li et al., provides a detailed pharmacological characterization of the ionic mechanisms that underlie rhythmic activity of retrotrapezoid nucleus neurons that control breathing. Specifically, the authors demonstrate a role of the transient receptor potential melastatin 4 (TRPM4) ion cha...
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| Main Authors: | , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
30 March 2021
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| In: |
Cell calcium
Year: 2021, Volume: 96, Pages: 1-3 |
| ISSN: | 1532-1991 |
| DOI: | 10.1016/j.ceca.2021.102401 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ceca.2021.102401 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0143416021000555 
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| Author Notes: | Wojciech Ambroziak, Jan Siemens |
| Summary: | The study by Li et al., provides a detailed pharmacological characterization of the ionic mechanisms that underlie rhythmic activity of retrotrapezoid nucleus neurons that control breathing. Specifically, the authors demonstrate a role of the transient receptor potential melastatin 4 (TRPM4) ion channel in the generation of subthreshold excitatory oscillations. Additionally, they propose that the ion channel contributes to tonic action potential (AP) firing - referred to as “pacemaking” - of these brainstem neurons with relevance for respiratory breathing and homeostasis in vivo. |
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| Item Description: | Gesehen am 14.07.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1532-1991 |
| DOI: | 10.1016/j.ceca.2021.102401 |