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Low pre-transplant Caveolin-1 serum concentrations are associated with acute cellular tubulointerstitial rejection in kidney transplantation

Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, protection from IRI could be favorable in terms of limiting g...

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Main Authors: Emmerich, Florian (Author) , Zschiedrich, Stefan (Author) , Reichenbach-Braun, Christine (Author) , Süsal, Caner (Author) , Minguet, Susana (Author) , Pauly, Marie-Christin (Author) , Seidl, Maximilian (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2021
In: Molecules
Year: 2021, Volume: 26, Issue: 9, Pages: 1-11
ISSN:1420-3049
DOI:10.3390/molecules26092648
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/molecules26092648
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1420-3049/26/9/2648
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Author Notes:Florian Emmerich, Stefan Zschiedrich, Christine Reichenbach-Braun, Caner Süsal, Susana Minguet, Marie-Christin Pauly and Maximilian Seidl
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Summary:Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, protection from IRI could be favorable in terms of limiting graft rejection. Caveolin-1 (Cav-1) is part of the cell membrane and an important regulator of intracellular signaling. Cav-1 has been demonstrated to limit IRI and to promote the survival of a variety of cell types including renal cells under stress conditions. Accordingly, Cav-1 could also play a role in limiting anti-graft immune responses. Here, we evaluated a possible association between pre-transplant serum concentrations of Cav-1 and the occurrence of rejection during follow-up in a pilot study. Therefore, Cav-1-serum concentrations were analyzed in 91 patients at the time of kidney transplantation and compared to the incidence of acute and chronic rejection. Higher Cav-1 levels were associated with lower occurrence of acute cellular tubulointerstitial rejection episodes.
Item Description:Gesehen am 15.07.2021
Physical Description:Online Resource
ISSN:1420-3049
DOI:10.3390/molecules26092648

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