Crossing the blood-brain barrier: a review on drug delivery strategies using colloidal carrier systems
The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in v...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 April 2021
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| In: |
Neurochemistry international
Year: 2021, Volume: 147 |
| ISSN: | 1872-9754 |
| DOI: | 10.1016/j.neuint.2021.105017 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neuint.2021.105017 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0197018621000632 
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| Author Notes: | Anne Mahringer, Elena Puris, Gert Fricker |
| Summary: | The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in vivo despite promising in vitro results. One approach to solve this problem is the delivery of drugs via surface modified nanocarrier systems. This review will give an overview on currently tested systems, mainly liposomes and solid nanoparticles and inform about new developments. |
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| Item Description: | Gesehen am 20.07.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1872-9754 |
| DOI: | 10.1016/j.neuint.2021.105017 |