The cleavage of spike protein НА0→НА1/HA2 by trypsin permits activation of the M2 channel without its proteolytic cleavage in the influenza A virus
M2 plays numerous regulatory roles in influenza A virus infection confirming the old adage: “a little body often harbors a great sense”. The comment here demonstrates that a small viral protein M2, having 14 kD m.w. and situating in the virion at a minor amount of only about 40 molecules per virus p...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 April 2021
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| In: |
Virology
Year: 2021, Volume: 559, Pages: 86-88 |
| ISSN: | 1096-0341 |
| DOI: | 10.1016/j.virol.2021.03.016 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.virol.2021.03.016 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0042682221000805 
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| Author Notes: | O.P. Zhirnov, P. Chlanda |
| Summary: | M2 plays numerous regulatory roles in influenza A virus infection confirming the old adage: “a little body often harbors a great sense”. The comment here demonstrates that a small viral protein M2, having 14 kD m.w. and situating in the virion at a minor amount of only about 40 molecules per virus particle is resistant to trypsin at concentrations initiating the HA0 cleavage and virus infectivity activation. A mechanism involving a programmed disassembly by cascade-type transmembrane signaling of the HA-M2-M1-RNP cooperation during virus entry into the infected cell is proposed. |
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| Item Description: | Gesehen am 26.07.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1096-0341 |
| DOI: | 10.1016/j.virol.2021.03.016 |