High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike r...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 June 2021
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| In: |
Communications biology
Year: 2021, Jahrgang: 4 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-021-02241-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42003-021-02241-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42003-021-02241-8 
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| Verfasserangaben: | Christiaan P. J. de Kock, Jean Pie, Anton W. Pieneman, Rebecca A. Mease, Arco Bast, Jason M. Guest, Marcel Oberlaender, Huibert D. Mansvelder & Bert Sakmann |
| Zusammenfassung: | Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spiking contains high-frequency bursts (≥100 Hz) in all morphological cell-types but a significant increase upon whisker touch is restricted to layer L5 thick-tufted pyramids (L5tts) and thus provides a distinct neurophysiological signature. We find that whisker touch can also be decoded from L5tt bursting, but not from other cell-types. We observed high-frequency bursts in L5tts projecting to different subcortical regions, including thalamus, midbrain and brainstem. We conclude that bursts in L5tts allow accurate coding and decoding of exploratory whisker touch. |
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| Beschreibung: | Gesehen am 26.07.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-021-02241-8 |