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Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma

Objective. To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC. Patients and Methods. Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous ( ) and ESCC ( ). Results. Expression of FXYD-3 in the...

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Hauptverfasser: Zhu, Zhen-Long (VerfasserIn) , Zentgraf, Hanswalter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 27 Aug 2013
In: Disease markers
Year: 2013, Jahrgang: 35, Heft: 3, Pages: 195-202
ISSN:1875-8630
DOI:10.1155/2013/740201
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2013/740201
Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/dm/2013/740201/
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Verfasserangaben:Zhen-Long Zhu, Bao-Yong Yan, Yu Zhang, Yan-Hong Yang, Ming-Wei Wang, Hanswalter Zentgraf, Xiang-Hong Zhang, and Xiao-Feng Sun
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Zusammenfassung:Objective. To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC. Patients and Methods. Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous ( ) and ESCC ( ). Results. Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( ). The expression of FXYD-3 was correlated with TNM stages and depth of tumor invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( ), and FXYD-3 expression tended to be positively related to the expression of PINCH ( ). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis ( ). However, FXYD-3 expression was not correlated with patient’s gender ( ), age ( ), tumor location ( ), size ( ), grade of differentiation ( ), and survival ( ). Conclusion. Overexpression of FXYD-3 in the cytoplasm may play an important role in the tumorigenesis and development in the human ESCC, particularly in combination with PINCH expression.
Beschreibung:Gesehen am 28.07.2021
Beschreibung:Online Resource
ISSN:1875-8630
DOI:10.1155/2013/740201

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