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FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo

Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolate...

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Main Authors: Kuhn, Christian (Author) , Menke, Maja (Author) , Senger, Frauke (Author) , Mack, Claudia (Author) , Dierck, Franziska (Author) , Hille, Susanne (Author) , Schmidt, Inga (Author) , Brunke, Gabriele (Author) , Bünger, Pia (Author) , Schmiedel, Nesrin (Author) , Will, Rainer D. (Author) , Sossalla, Samuel (Author) , Frank, Derk (Author) , Eschenhagen, Thomas (Author) , Carrier, Lucie (Author) , Lüllmann-Rauch, Renate (Author) , Rangrez, Ashraf Yusuf (Author) , Frey, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 17 March 2021
In: JACC Basic to translational science
Year: 2021, Volume: 6, Issue: 4, Pages: 365-380
ISSN:2452-302X
DOI:10.1016/j.jacbts.2021.01.001
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jacbts.2021.01.001
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2452302X21000061
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Author Notes:Christian Kuhn, MD, Maja Menke, MD, Frauke Senger, Claudia Mack, MD, Franziska Dierck, PHD, Susanne Hille, Inga Schmidt, Gabriele Brunke, Pia Bünger, Nesrin Schmiedel, Rainer Will, PHD, Samuel Sossalla, MD, Derk Frank, MD, Thomas Eschenhagen, MD, Lucie Carrier, PHD, Renate Lüllmann-Rauch, MD, Ashraf Yusuf Rangrez, PHD, Norbert Frey, MD
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Summary:Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.
Item Description:Gesehen am 28.07.2021
Physical Description:Online Resource
ISSN:2452-302X
DOI:10.1016/j.jacbts.2021.01.001

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