Harnessing mesenchymal stromal cells for the engineering of human hematopoietic niches
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing and modelling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of imm...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 March 2021
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| In: |
Frontiers in immunology
Year: 2021, Volume: 12, Pages: 1-17 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.631279 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2021.631279 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.631279/full 
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| Author Notes: | Alice Pievani, Roberto Savoldelli, Juliane Poelchen, Elisa Mattioli, Giorgio Anselmi, Alice Girardot, Jochen Utikal, Pierre Bourdely, Marta Serafini and Pierre Guermonprez |
| Summary: | Tissue engineering opens multiple opportunities in regenerative medicine, drug testing and modelling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo. |
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| Item Description: | Gesehen am 29.07.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.631279 |