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α-synuclein interacts with SOD1 and promotes its oligomerization

Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD whereas Cu, Zn superoxide dismutase (SOD1) is a key player in a subset of familial ALS cases. Und...

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Main Authors: Helferich, Anika Marie (Author) , Ruf, Wolfgang P. (Author) , Grozdanov, Veselin (Author) , Freischmidt, Axel (Author) , Feiler, Marisa S. (Author) , Zondler, Lisa (Author) , Ludolph, Albert C. (Author) , McLean, Pamela J. (Author) , Weishaupt, Jochen H. (Author) , Danzer, Karin M. (Author)
Format: Article (Journal)
Language:English
Published: 08 December 2015
In: Molecular neurodegeneration
Year: 2015, Volume: 10, Pages: 1-16
ISSN:1750-1326
DOI:10.1186/s13024-015-0062-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13024-015-0062-3
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Author Notes:Anika M. Helferich, Wolfgang P. Ruf, Veselin Grozdanov, Axel Freischmidt, Marisa S. Feiler, Lisa Zondler, Albert C. Ludolph, Pamela J. McLean, Jochen H. Weishaupt and Karin M. Danzer
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Summary:Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD whereas Cu, Zn superoxide dismutase (SOD1) is a key player in a subset of familial ALS cases. Under pathological conditions both α-synuclein and SOD1 form oligomers and fibrils. In this study we investigated the possible molecular interaction of α-synuclein and SOD1 and its functional and pathological relevance.
Item Description:Gesehen am 29.07.2021
Physical Description:Online Resource
ISSN:1750-1326
DOI:10.1186/s13024-015-0062-3

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