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A disulfide-constrained miniprotein with striking tumor-binding specificity developed by ribosome display

Fold me to hold me: A specific binding agent against the delta-like ligand 4 protein, which is expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of this molecular imaging agent depends on the appropriate disulfide connectivity of its scaffold.

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Bibliographic Details
Main Authors: Zoller, Frederic (Author) , Hebling, Ulrike (Author) , Altmann, Annette (Author) , Lindner, Thomas (Author) , Mier, Walter (Author) , Haberkorn, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 20 September 2013
In: Angewandte Chemie. International edition
Year: 2013, Volume: 52, Issue: 45, Pages: 11760-11764
ISSN:1521-3773
DOI:10.1002/anie.201304603
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201304603
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201304603
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Author Notes:Frederic Zoller, Annette Markert, Philippe Barthe, Ulrike Hebling, Annette Altmann, Thomas Lindner, Walter Mier, and Uwe Haberkorn
Description
Summary:Fold me to hold me: A specific binding agent against the delta-like ligand 4 protein, which is expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of this molecular imaging agent depends on the appropriate disulfide connectivity of its scaffold.
Item Description:Gesehen am 02.08.2021
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201304603

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