A disulfide-constrained miniprotein with striking tumor-binding specificity developed by ribosome display
Fold me to hold me: A specific binding agent against the delta-like ligand 4 protein, which is expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of this molecular imaging agent depends on the appropriate disulfide connectivity of its scaffold.
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 September 2013
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| In: |
Angewandte Chemie. International edition
Year: 2013, Jahrgang: 52, Heft: 45, Pages: 11760-11764 |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201304603 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201304603 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201304603 
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| Verfasserangaben: | Frederic Zoller, Annette Markert, Philippe Barthe, Ulrike Hebling, Annette Altmann, Thomas Lindner, Walter Mier, and Uwe Haberkorn |
| Zusammenfassung: | Fold me to hold me: A specific binding agent against the delta-like ligand 4 protein, which is expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of this molecular imaging agent depends on the appropriate disulfide connectivity of its scaffold. |
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| Beschreibung: | Gesehen am 02.08.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1521-3773 |
| DOI: | 10.1002/anie.201304603 |