Cover Image

Vascular macrophages as therapeutic targets to treat intracranial aneurysms

Aneurysmal subarachnoid hemorrhage (aSAH) is a highly fatal and morbid type of hemorrhagic strokes. Intracranial aneurysms (ICAs) rupture cause subarachnoid hemorrhage. ICAs formation, growth and rupture involves cellular and molecular inflammation. Macrophages orchestrate inflammation in the wall o...

Full description

Saved in:
Bibliographic Details
Main Authors: Muḥammad, Sajjad (Author) , Chaudhry, Shafqat Rasul (Author) , Dobreva, Gergana (Author) , Lawton, Michael T. (Author) , Niemelä, Mika (Author) , Hänggi, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 08 March 2021
In: Frontiers in immunology
Year: 2021, Volume: 12, Pages: 1-12
ISSN:1664-3224
DOI:10.3389/fimmu.2021.630381
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2021.630381
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.630381/full
Get full text
Author Notes:Sajjad Muhammad, Shafqat Rasul Chaudhry, Gergana Dobreva, Michael T. Lawton, Mika Niemelä and Daniel Hänggi
Description
Summary:Aneurysmal subarachnoid hemorrhage (aSAH) is a highly fatal and morbid type of hemorrhagic strokes. Intracranial aneurysms (ICAs) rupture cause subarachnoid hemorrhage. ICAs formation, growth and rupture involves cellular and molecular inflammation. Macrophages orchestrate inflammation in the wall of ICAs. Macrophages generally polarize either into classical inflammatory (M1) or alternatively-activated anti-inflammatory (M2)-phenotype. Macrophage infiltration and polarization towards M1-phenotype increases the risk of aneurysm rupture. Strategies that deplete, inhibit infiltration, ameliorate macrophage inflammation or polarize to M2-type protect against ICAs rupture. However, clinical translational data is still lacking. This review summarizes the contribution of macrophage led inflammation in the aneurysm wall and discuss pharmacological strategies to modulate the macrophageal response during ICAs formation and rupture.
Item Description:Gesehen am 11.08.2021
Physical Description:Online Resource
ISSN:1664-3224
DOI:10.3389/fimmu.2021.630381

Similar Items