Buchumschlag

Vascular macrophages as therapeutic targets to treat intracranial aneurysms

Aneurysmal subarachnoid hemorrhage (aSAH) is a highly fatal and morbid type of hemorrhagic strokes. Intracranial aneurysms (ICAs) rupture cause subarachnoid hemorrhage. ICAs formation, growth and rupture involves cellular and molecular inflammation. Macrophages orchestrate inflammation in the wall o...

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Bibliographische Detailangaben
Hauptverfasser: Muḥammad, Sajjad (VerfasserIn) , Chaudhry, Shafqat Rasul (VerfasserIn) , Dobreva, Gergana (VerfasserIn) , Lawton, Michael T. (VerfasserIn) , Niemelä, Mika (VerfasserIn) , Hänggi, Daniel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 08 March 2021
In: Frontiers in immunology
Year: 2021, Jahrgang: 12, Pages: 1-12
ISSN:1664-3224
DOI:10.3389/fimmu.2021.630381
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2021.630381
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.630381/full
Volltext
Verfasserangaben:Sajjad Muhammad, Shafqat Rasul Chaudhry, Gergana Dobreva, Michael T. Lawton, Mika Niemelä and Daniel Hänggi

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520 |a Aneurysmal subarachnoid hemorrhage (aSAH) is a highly fatal and morbid type of hemorrhagic strokes. Intracranial aneurysms (ICAs) rupture cause subarachnoid hemorrhage. ICAs formation, growth and rupture involves cellular and molecular inflammation. Macrophages orchestrate inflammation in the wall of ICAs. Macrophages generally polarize either into classical inflammatory (M1) or alternatively-activated anti-inflammatory (M2)-phenotype. Macrophage infiltration and polarization towards M1-phenotype increases the risk of aneurysm rupture. Strategies that deplete, inhibit infiltration, ameliorate macrophage inflammation or polarize to M2-type protect against ICAs rupture. However, clinical translational data is still lacking. This review summarizes the contribution of macrophage led inflammation in the aneurysm wall and discuss pharmacological strategies to modulate the macrophageal response during ICAs formation and rupture. 
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