SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition
Background & aims - In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 2021
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| In: |
Clinical nutrition
Year: 2021, Volume: 40, Issue: 4, Pages: 1487-1494 |
| ISSN: | 1532-1983 |
| DOI: | 10.1016/j.clnu.2021.02.023 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clnu.2021.02.023 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0261561421000972 
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| Author Notes: | Lierni Ugartemendia, Rafael Bravo, Martin Reuter, M. Yolanda Castaño, Thomas Plieger, Vera Zamoscik, Peter Kirsch, Ana B. Rodríguez |
| Summary: | Background & aims - In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also known as serotonin transporter (SERT1) gene. - Methods - 91 young volunteers (age: 21 ± 2 yrs) and 127 above 50 years old (58 ± 6 yrs) healthy volunteers completed the study. Participants from the placebo and tryptophan group followed the same protocol. Before starting the study blood samples, to measure serotonin-transporter-linked polymorphic region (5-HTTLPR) and rs25531 polymorphisms, were collected. In addition, before and after completing the study urine samples (to measure 5-hydroxyindolacetic acid (5-HIAA) were taken, while psychological questionnaires (to assess depression and social cognition levels), and a one week dietary record (to calculate the tryptophan (TRP) intake) were assessed. - Results - The triallelic approach of SLC6A4 showed that in S'S´ subjects there was a positive correlation between TRP intake and 5-HIAA levels. Age of participants, SLC6A4 genotype, and experimental condition were important factors contributing to the outcome of depression and social cognition. - Conclusions - 5-HTTLPR and rs25531 polymorphisms play a key role in the response to the TRP- based nutritional intervention, improving only age-related depressive symptoms and empathy in S'S´ subjects who have a higher risk to show signs of depression during their lifetime. |
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| Item Description: | Gesehen am 11.08.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1532-1983 |
| DOI: | 10.1016/j.clnu.2021.02.023 |