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Susceptibility-weighted 3T MRI of the swallow tail sign in multiple sclerosis: a case control study

BACKGROUND AND PURPOSE The swallow tail sign describes the physiological appearance of nigrosome-1 within the substantia nigra on high-resolution transverse susceptibility-weighted imaging (SWI). Previous studies demonstrated its absence in Parkinson's disease due to increasing iron content. In...

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Bibliographic Details
Main Authors: Weber, Claudia Ellen (Author) , Ebert, Anne (Author) , Platten, Michael (Author) , Gass, Achim (Author) , Eisele, Philipp (Author)
Format: Article (Journal)
Language:English
Published: 28 August 2020
In: Journal of neuroimaging
Year: 2020, Volume: 30, Issue: 6, Pages: 766-768
ISSN:1552-6569
DOI:10.1111/jon.12775
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/jon.12775
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12775
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Author Notes:Claudia E. Weber, Anne Ebert, Michael Platten, Achim Gass, and Philipp Eisele
Description
Summary:BACKGROUND AND PURPOSE The swallow tail sign describes the physiological appearance of nigrosome-1 within the substantia nigra on high-resolution transverse susceptibility-weighted imaging (SWI). Previous studies demonstrated its absence in Parkinson's disease due to increasing iron content. In multiple sclerosis (MS), increased iron accumulation can be found in the brain tissue including the substantia nigra. METHODS We investigated the swallow tail sign on high-resolution SWI MRI in 46 MS and 23 age- and sex-matched controls. RESULTS MS patients demonstrated significantly more often an abnormal swallow tail sign (28/46; 60%) compared to controls (4/23; 17%; P = .001). In MS patients, we found no correlation between an abnormal swallow tail sign and age, disease duration or Expanded Disability Status Scale scores. CONCLUSION The finding of an abnormal swallow tail sign in MS patients may provide an additional imaging marker even in early MS development.
Item Description:Gesehen am 16.08.2021
Physical Description:Online Resource
ISSN:1552-6569
DOI:10.1111/jon.12775

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