Susceptibility-weighted 3T MRI of the swallow tail sign in multiple sclerosis: a case control study
BACKGROUND AND PURPOSE The swallow tail sign describes the physiological appearance of nigrosome-1 within the substantia nigra on high-resolution transverse susceptibility-weighted imaging (SWI). Previous studies demonstrated its absence in Parkinson's disease due to increasing iron content. In...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 August 2020
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| In: |
Journal of neuroimaging
Year: 2020, Jahrgang: 30, Heft: 6, Pages: 766-768 |
| ISSN: | 1552-6569 |
| DOI: | 10.1111/jon.12775 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/jon.12775 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12775 
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| Verfasserangaben: | Claudia E. Weber, Anne Ebert, Michael Platten, Achim Gass, and Philipp Eisele |
| Zusammenfassung: | BACKGROUND AND PURPOSE The swallow tail sign describes the physiological appearance of nigrosome-1 within the substantia nigra on high-resolution transverse susceptibility-weighted imaging (SWI). Previous studies demonstrated its absence in Parkinson's disease due to increasing iron content. In multiple sclerosis (MS), increased iron accumulation can be found in the brain tissue including the substantia nigra. METHODS We investigated the swallow tail sign on high-resolution SWI MRI in 46 MS and 23 age- and sex-matched controls. RESULTS MS patients demonstrated significantly more often an abnormal swallow tail sign (28/46; 60%) compared to controls (4/23; 17%; P = .001). In MS patients, we found no correlation between an abnormal swallow tail sign and age, disease duration or Expanded Disability Status Scale scores. CONCLUSION The finding of an abnormal swallow tail sign in MS patients may provide an additional imaging marker even in early MS development. |
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| Beschreibung: | Gesehen am 16.08.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1552-6569 |
| DOI: | 10.1111/jon.12775 |