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A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and me...

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Main Authors: Raut, Janhavi R. (Author) , Schöttker, Ben (Author) , Holleczek, Bernd (Author) , Guo, Feng (Author) , Bhardwaj, Megha (Author) , Miah, Kaya (Author) , Schrotz-King, Petra (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 10 August 2021
In: Nature Communications
Year: 2021, Volume: 12, Pages: 1-9
ISSN:2041-1723
DOI:10.1038/s41467-021-25067-8
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-25067-8
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-25067-8
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Author Notes:Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King & Hermann Brenner
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Summary:Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95% CI) is 0.557 (0.498-0.616) for the ERS and 0.622 (0.564-0.681) for the PRS.
Item Description:Gesehen am 17.08.2021
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-021-25067-8

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