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Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms.

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Bibliographic Details
Main Authors: Rengelshausen, Jens (Author) , Göggelmann, Christoph (Author) , Burhenne, Jürgen (Author) , Riedel, Klaus-Dieter (Author) , Ludwig, Jochen (Author) , Weiß, Johanna (Author) , Mikus, Gerd (Author) , Walter-Sack, Ingeborg (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 2003
In: British journal of clinical pharmacology
Year: 2003, Volume: 56, Issue: 1, Pages: 32-38
ISSN:1365-2125
DOI:10.1046/j.1365-2125.2003.01824.x
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2125.2003.01824.x
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884337/
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Author Notes:Jens Rengelshausen, Christoph Göggelmann, Jürgen Burhenne, Klaus-Dieter Riedel, Jochen Ludwig, Johanna Weiss, Gerd Mikus, Ingeborg Walter-Sack & Walter E Haefeli
Description
Summary:A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms.
Item Description:Gesehen am 17.08.2021
Physical Description:Online Resource
ISSN:1365-2125
DOI:10.1046/j.1365-2125.2003.01824.x

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