Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms.

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Bibliographische Detailangaben
Hauptverfasser: Rengelshausen, Jens (VerfasserIn) , Göggelmann, Christoph (VerfasserIn) , Burhenne, Jürgen (VerfasserIn) , Riedel, Klaus-Dieter (VerfasserIn) , Ludwig, Jochen (VerfasserIn) , Weiß, Johanna (VerfasserIn) , Mikus, Gerd (VerfasserIn) , Walter-Sack, Ingeborg (VerfasserIn) , Haefeli, Walter E. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2003
In: British journal of clinical pharmacology
Year: 2003, Jahrgang: 56, Heft: 1, Pages: 32-38
ISSN:1365-2125
DOI:10.1046/j.1365-2125.2003.01824.x
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2125.2003.01824.x
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884337/
Volltext
Verfasserangaben:Jens Rengelshausen, Christoph Göggelmann, Jürgen Burhenne, Klaus-Dieter Riedel, Jochen Ludwig, Johanna Weiss, Gerd Mikus, Ingeborg Walter-Sack & Walter E Haefeli
Beschreibung
Zusammenfassung:A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms.
Beschreibung:Gesehen am 17.08.2021
Beschreibung:Online Resource
ISSN:1365-2125
DOI:10.1046/j.1365-2125.2003.01824.x