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Charge matters: modulating secondary interactions in hyaluronan hydrogels

Hyaluronic acid (HA) is a vital, functional component of the extracellular matrix (ECM). Following a synthetic biology approach, we designed polyelectrolyte hydrogels composed of HA as a polymeric backbone interconnected by short covalent crosslinkers. Utilizing a thiol-Michael addition, defined net...

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Bibliographic Details
Main Authors: Mundinger, Patricia (Author) , Kupka, Julia Stefanie (Author) , Minsky, Burcu Baykal (Author) , Schädel, Nicole (Author) , Petri, Nadja (Author) , Laschat, Sabine (Author) , Böhm, Heike (Author)
Format: Article (Journal)
Language:English
Published: 05 September 2017
In: ChemistrySelect
Year: 2017, Volume: 2, Issue: 25, Pages: 7701-7705
ISSN:2365-6549
DOI:10.1002/slct.201701908
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/slct.201701908
Verlag, lizenzpflichtig, Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.201701908
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Author Notes:Patricia S. Hegger, Julia Kupka, Burcu Baykal Minsky, Nicole Schädel, Nadja Petri, Sabine Laschat, and Heike Boehm
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Summary:Hyaluronic acid (HA) is a vital, functional component of the extracellular matrix (ECM). Following a synthetic biology approach, we designed polyelectrolyte hydrogels composed of HA as a polymeric backbone interconnected by short covalent crosslinkers. Utilizing a thiol-Michael addition, defined network structures are created, which can be modulated by the aromatic core and charge of the crosslinkers. With increasing negative network charge, varied both through the charge of the crosslinker and the degree of functionalization of the HA chain, the Young's modulus of the hydrogels decreases linearly as swelling ratios increase. Interestingly, secondary interactions with aromatic crosslinkers are stronger for elastin inspired crosslinkers with a pyridinium core compared to analogous triazolium crosslinkers. Based on the defined covalent interconnectivity of these HA-hydrogels, we were able to demonstrate the specific electrostatic and aromatic interactions induced by different short crosslinkers.
Item Description:Gesehen am 17.08.2021
Physical Description:Online Resource
ISSN:2365-6549
DOI:10.1002/slct.201701908

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