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Parkinson mice show functional and molecular changes in the gut long before motoric disease onset

There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain is already destroyed, so that the lack of early biomarke...

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Main Authors: Gries, Manuela (Author) , Christmann, Anne (Author) , Schulte, Steven (Author) , Weyland, Maximilian (Author) , Rommel, Stephanie (Author) , Martin, Monika (Author) , Baller, Marko (Author) , Röth, Ralph (Author) , Mellein, Stefanie (Author) , Unger, Marcus (Author) , Liu, Yang (Author) , Sommer, Frederik (Author) , Mühlhaus, Timo (Author) , Schroda, Michael (Author) , Timmermans, Jean-Pierre (Author) , Pintelon, Isabel (Author) , Rappold, Gudrun (Author) , Britschgi, Markus (Author) , Lashuel, Hilal (Author) , Menger, Michael D. (Author) , Laschke, Matthias W. (Author) , Niesler, Beate (Author) , Schäfer, Karl Herbert (Author)
Format: Article (Journal)
Language:English
Published: 02 June 2021
In: Molecular neurodegeneration
Year: 2021, Volume: 16, Pages: 1-23
ISSN:1750-1326
DOI:10.1186/s13024-021-00439-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13024-021-00439-2
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Author Notes:Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun A. Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler and Karl-Herbert Schäfer
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Summary:There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain is already destroyed, so that the lack of early biomarkers for the disease represents a major challenge for developing timely treatment interventions. Here, we use a transgenic A30P-α-synuclein-overexpressing PD mouse model to identify appropriate candidate markers in the gut before hallmark symptoms begin to manifest.
Item Description:Gesehen am 18.08.2021
Physical Description:Online Resource
ISSN:1750-1326
DOI:10.1186/s13024-021-00439-2

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