Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited.
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
03 June 2021
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| In: |
Respiratory research
Year: 2021, Jahrgang: 22, Pages: 1-11 |
| ISSN: | 1465-993X |
| DOI: | 10.1186/s12931-021-01759-z |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12931-021-01759-z |
| Verfasserangaben: | Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz and Frauke Pedersen, on behalf of the ALLIANCE study group |
| Zusammenfassung: | Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited. |
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| Beschreibung: | Gesehen am 19.08.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 1465-993X |
| DOI: | 10.1186/s12931-021-01759-z |