Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma

Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited.

Bibliographic Details

Main Authors:	Abdo, Mustafa (Author) , Uddin, Mohib (Author) , Goldmann, Torsten (Author) , Marwitz, Sebastian (Author) , Bahmer, Thomas (Author) , Holz, Olaf (Author) , Kirsten, Anne-Marie (Author) , Trinkmann, Frederik (Author) , von Mutius, Erika (Author) , Kopp, Matthias (Author) , Hansen, Gesine (Author) , Rabe, Klaus F. (Author) , Watz, Henrik (Author) , Pedersen, Frauke (Author)
Format:	Article (Journal)
Language:	English
Published:	03 June 2021
In:	Respiratory research Year: 2021, Volume: 22, Pages: 1-11
ISSN:	1465-993X
DOI:	10.1186/s12931-021-01759-z
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12931-021-01759-z
Author Notes:	Mustafa Abdo, Mohib Uddin, Torsten Goldmann, Sebastian Marwitz, Thomas Bahmer, Olaf Holz, Anne-Marie Kirsten, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Henrik Watz and Frauke Pedersen, on behalf of the ALLIANCE study group