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Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying protection in younger age groups remain unknown. Here we...

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Hauptverfasser: Loske, Jennifer (VerfasserIn) , Röhmel, J. (VerfasserIn) , Lukassen, S. (VerfasserIn) , Stricker, S. (VerfasserIn) , Magalhães, V. G. (VerfasserIn) , Liebig, J. (VerfasserIn) , Chua, R. L. (VerfasserIn) , Thürmann, L. (VerfasserIn) , Messingschlager, M. (VerfasserIn) , Seegebarth, A. (VerfasserIn) , Timmermann, B. (VerfasserIn) , Klages, S. (VerfasserIn) , Ralser, M. (VerfasserIn) , Sawitzki, B. (VerfasserIn) , Sander, L. E. (VerfasserIn) , Corman, V. M. (VerfasserIn) , Conrad, C. (VerfasserIn) , Laudi, S. (VerfasserIn) , Binder, Marco (VerfasserIn) , Trump, S. (VerfasserIn) , Eils, Roland (VerfasserIn) , Mall, M. A. (VerfasserIn) , Lehmann, I. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 August 2021
In: Nature biotechnology
Year: 2021, Jahrgang: 40
ISSN:1546-1696
DOI:10.1038/s41587-021-01037-9
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41587-021-01037-9
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41587-021-01037-9
Volltext
Verfasserangaben:J. Loske, J. Röhmel, S. Lukassen, S. Stricker, V.G. Magalhães, J. Liebig, R.L. Chua, L. Thürmann, M. Messingschlager, A. Seegebarth, B. Timmermann, S. Klages, M. Ralser, B. Sawitzki, L.E. Sander, V.M. Corman, C. Conrad, S. Laudi, M. Binder, S. Trump, R. Eils, M.A. Mall and I. Lehmann
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Zusammenfassung:Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying protection in younger age groups remain unknown. Here we characterize the single-cell transcriptional landscape in the upper airways of SARS-CoV-2-negative (n = 18) and age-matched SARS-CoV-2-positive (n = 24) children and corresponding samples from adults (n = 44), covering an age range of 4 weeks to 77 years. Children displayed higher basal expression of relevant pattern recognition receptors such as MDA5 (IFIH1) and RIG-I (DDX58) in upper airway epithelial cells, macrophages and dendritic cells, resulting in stronger innate antiviral responses upon SARS-CoV-2 infection than in adults. We further detected distinct immune cell subpopulations including KLRC1 (NKG2A)+ cytotoxic T cells and a CD8+ T cell population with a memory phenotype occurring predominantly in children. Our study provides evidence that the airway immune cells of children are primed for virus sensing, resulting in a stronger early innate antiviral response to SARS-CoV-2 infection than in adults.
Beschreibung:Das PDF enthält zusätzlich einen Anhang von 9 Seiten
Gesehen am 19.08.2021
Beschreibung:Online Resource
ISSN:1546-1696
DOI:10.1038/s41587-021-01037-9

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