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GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium: potential biomarkers in the detection of endometriosis - a pilot study

Endometriosis (EM) is a common gynecological disease affecting 10-15% of women of reproductive age. However, molecular mechanisms and pathogenesis are still not completely understood. Furthermore, due to the absence of a reliable clinical biomarker, the only viable method for the often-delayed defin...

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Bibliographic Details
Main Authors: Holzer, Isabell (Author) , Machado Weber, Amanda (Author) , Marshall, Anne (Author) , Freis, Alexander (Author) , Jauckus, Julia (Author) , Strowitzki, Thomas (Author) , Germeyer, Ariane (Author)
Format: Article (Journal)
Language:English
Published: 07 October 2020
In: Journal of assisted reproduction and genetics
Year: 2020, Volume: 37, Issue: 11, Pages: 2723-2732
ISSN:1573-7330
DOI:10.1007/s10815-020-01905-4
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10815-020-01905-4
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Author Notes:Isabell Holzer, Amanda Machado Weber, Anne Marshall, Alexander Freis, Julia Jauckus, Thomas Strowitzki, Ariane Germeyer
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Summary:Endometriosis (EM) is a common gynecological disease affecting 10-15% of women of reproductive age. However, molecular mechanisms and pathogenesis are still not completely understood. Furthermore, due to the absence of a reliable clinical biomarker, the only viable method for the often-delayed definitive diagnosis is laparoscopic surgery. Our objective was to analyze molecular differences of selected endometrial proteins and genes of women suffering from different stages of EM compared with healthy women to evaluate potential clinical biomarkers.
Item Description:Gesehen am 31.08.2021
Physical Description:Online Resource
ISSN:1573-7330
DOI:10.1007/s10815-020-01905-4

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