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An increased bone mineral density is an adverse prognostic factor in patients with systemic mastocytosis

Systemic mastocytosis (SM) is characterized by the expansion of clonal mast cells that infiltrate various organ systems. The extent of organ infiltration and subsequent organ damage distinguishes between indolent SM (ISM) defined by a nearly normal life expectancy and advanced SM (AdvSM) defined by...

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Bibliographic Details
Main Authors: Riffel, Philipp (Author) , Schwaab, Juliana (Author) , Lutz, Christopher (Author) , Naumann, Nicole (Author) , Metzgeroth, Georgia (Author) , Fabarius, Alice (Author) , Schönberg, Stefan (Author) , Hofmann, Wolf-Karsten (Author) , Valent, Peter (Author) , Reiter, Andreas (Author) , Jawhar, Mohamad (Author)
Format: Article (Journal)
Language:English
Published: 24 January 2020
In: Journal of cancer research and clinical oncology
Year: 2020, Volume: 146, Issue: 4, Pages: 945-951
ISSN:1432-1335
DOI:10.1007/s00432-019-03119-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00432-019-03119-3
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Author Notes:Philipp Riffel, Juliana Schwaab, Christopher Lutz, Nicole Naumann, Georgia Metzgeroth, Alice Fabarius, Stefan O. Schoenberg, Wolf-Karsten Hofmann, Peter Valent, Andreas Reiter, Mohamad Jawhar
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Summary:Systemic mastocytosis (SM) is characterized by the expansion of clonal mast cells that infiltrate various organ systems. The extent of organ infiltration and subsequent organ damage distinguishes between indolent SM (ISM) defined by a nearly normal life expectancy and advanced SM (AdvSM) defined by poor prognosis. In ISM, measurement of the bone mineral density (BMD) frequently reveals osteoporosis. In contrast, the clinical implication of an increased BMD and osteosclerosis remains unclear.
Item Description:Gesehen am 01.09.2021
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-019-03119-3

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