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Hepatitis B virus DNA integration: in vitro models for investigating viral pathogenesis and persistence

Hepatitis B virus (HBV) is a globally-distributed pathogen and is a major cause of liver disease. HBV (or closely-related animal hepadnaviruses) can integrate into the host genome, but (unlike retroviruses) this integrated form is replication-defective. The specific role(s) of the integrated HBV DNA...

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Bibliographic Details
Main Authors: Tu, Thomas (Author) , Zhang, Henrik (Author) , Urban, Stephan (Author)
Format: Article (Journal)
Language:English
Published: 26 January 2021
In: Viruses
Year: 2021, Volume: 13, Issue: 2, Pages: 1-16
ISSN:1999-4915
DOI:10.3390/v13020180
Online Access:Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1999-4915/13/2/180
Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/v13020180
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911709
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Author Notes:Thomas Tu, Henrik Zhang and Stephan Urban
Description
Summary:Hepatitis B virus (HBV) is a globally-distributed pathogen and is a major cause of liver disease. HBV (or closely-related animal hepadnaviruses) can integrate into the host genome, but (unlike retroviruses) this integrated form is replication-defective. The specific role(s) of the integrated HBV DNA has been a long-standing topic of debate. Novel in vitro models of HBV infection combined with sensitive molecular assays now enable researchers to investigate this under-characterised phenomenon with greater ease and precision. This review covers the contributions these systems have made to understanding how HBV DNA integration induces liver cancer and facilitates viral persistence. We summarise the current findings into a working model of chronic HBV infection and discuss the clinical implications of this hypothetical framework on the upcoming therapeutic strategies used to curb HBV-associated pathogenesis.
Item Description:Gesehen am 03.09.2021
Physical Description:Online Resource
ISSN:1999-4915
DOI:10.3390/v13020180

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