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Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study

Introduction Beta-cell autoantibodies are established markers of autoimmunity, which we compared between Ghanaian adults with or without diabetes, living in rural and urban Ghana and in three European cities. Methods In the multicenter cross-sectional Research on Obesity and Diabetes among African M...

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Main Authors: Hampe, Christiane S. (Author) , Sahabandu, Diomira (Author) , Kaiser, Vivien (Author) , Telieps, Tanja (Author) , Smeeth, Liam (Author) , Agyemang, Charles (Author) , Spranger, Joachim (Author) , Schulze, Matthias B. (Author) , Mockenhaupt, Frank P. (Author) , Danquah, Ina (Author) , Rolandsson, Olov (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Immunity, Inflammation and Disease
Year: 2020, Volume: 8, Issue: 3, Pages: 299-309
ISSN:2050-4527
DOI:10.1002/iid3.306
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/iid3.306
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.306
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Author Notes:Christiane S. Hampe, Diomira Sahabandu, Vivien Kaiser, Tanja Telieps, Liam Smeeth, Charles Agyemang, Joachim Spranger, Matthias B. Schulze, Frank P. Mockenhaupt, Ina Danquah, Olov Rolandsson
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Summary:Introduction Beta-cell autoantibodies are established markers of autoimmunity, which we compared between Ghanaian adults with or without diabetes, living in rural and urban Ghana and in three European cities. Methods In the multicenter cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) study (N = 5898), we quantified autoantibodies against glutamic acid decarboxylase (GAD65Ab) by radioligand binding assay (RBA) and established cut-offs for positivity by displacement analysis. In a subsample, we performed RBA for zinc transporter-8 autoantibodies (ZnT8Ab). Associations of environmental, sociodemographic, and clinical factors with GAD65Ab were calculated. Results In this study population (age: 46.1 ± 11.9 years; female: 62%; Ghana-rural: 1111; Ghana-urban: 1455; Europe: 3332), 9.2% had diabetes with adult-onset. GAD65Ab concentrations were the highest in Ghana-rural (32.4; 10.8-71.3 U/mL), followed by Ghana-urban (26.0; 12.3-49.1 U/mL) and Europe (11.9; 3.0-22.8 U/mL) with no differences between European cities. These distributions were similar for ZnT8Ab. Current fever, history of fever, and higher concentrations of liver enzymes marginally explained site-specific GAD65Ab concentrations. GAD65Ab positivity was as frequent in diabetes as in nondiabetes (5.4% vs 6.1%; P = .25). This was also true for ZnT8Ab positivity. Conclusion Geographic location determines the occurrence of GAD65Ab and ZnT8Ab more than the diabetes status. Beta-cell autoimmunity may not be feasible to differentiate diabetes subgroups in this population.
Item Description:First published: 07 May 2020
Gesehen am 08.09.2021
Physical Description:Online Resource
ISSN:2050-4527
DOI:10.1002/iid3.306

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