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Review alternative polyadenylation in stem cell self-renewal and differentiation

Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA...

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Bibliographic Details
Main Authors: Sommerkamp, Pia (Author) , Cabezas Wallscheid, Nina (Author) , Trumpp, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 11 May 2021
In: Trends in molecular medicine
Year: 2021, Volume: 27, Issue: 7, Pages: 660-672
ISSN:1471-499X
DOI:10.1016/j.molmed.2021.04.006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmed.2021.04.006
Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2Fj.molmed.2021.04.006&DestApp=DOI&SrcAppSID=C2yaq1zUN4YUOwlDSEZ&SrcJTitle=TRENDS+IN+MOLECULAR+MEDICINE&DestDOIRegistrantName=Elsevier
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Author Notes:Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp
Description
Summary:Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine.
Item Description:Gesehen am 10.09.2021
Physical Description:Online Resource
ISSN:1471-499X
DOI:10.1016/j.molmed.2021.04.006

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