Review alternative polyadenylation in stem cell self-renewal and differentiation
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 May 2021
|
| In: |
Trends in molecular medicine
Year: 2021, Volume: 27, Issue: 7, Pages: 660-672 |
| ISSN: | 1471-499X |
| DOI: | 10.1016/j.molmed.2021.04.006 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmed.2021.04.006 Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2Fj.molmed.2021.04.006&DestApp=DOI&SrcAppSID=C2yaq1zUN4YUOwlDSEZ&SrcJTitle=TRENDS+IN+MOLECULAR+MEDICINE&DestDOIRegistrantName=Elsevier 
|
| Author Notes: | Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1770007040 | ||
| 003 | DE-627 | ||
| 005 | 20230427183140.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210910s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.molmed.2021.04.006 |2 doi | |
| 035 | |a (DE-627)1770007040 | ||
| 035 | |a (DE-599)KXP1770007040 | ||
| 035 | |a (OCoLC)1341420626 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sommerkamp, Pia |e VerfasserIn |0 (DE-588)1191847837 |0 (DE-627)1670317099 |4 aut | |
| 245 | 1 | 0 | |a Review alternative polyadenylation in stem cell self-renewal and differentiation |c Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp |
| 264 | 1 | |c 11 May 2021 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.09.2021 | ||
| 520 | |a Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine. | ||
| 650 | 4 | |a 3' untranslated regions | |
| 650 | 4 | |a 3'-end cleavage | |
| 650 | 4 | |a c-myc | |
| 650 | 4 | |a cleavage factor-i | |
| 650 | 4 | |a gene-expression | |
| 650 | 4 | |a neuronal differentiation | |
| 650 | 4 | |a pre-messenger-rna | |
| 650 | 4 | |a protein | |
| 650 | 4 | |a regenerative medicine | |
| 650 | 4 | |a signal | |
| 700 | 1 | |a Cabezas Wallscheid, Nina |d 1982- |e VerfasserIn |0 (DE-588)141488085 |0 (DE-627)62942862X |0 (DE-576)324105959 |4 aut | |
| 700 | 1 | |a Trumpp, Andreas |d 1964- |e VerfasserIn |0 (DE-588)1081774134 |0 (DE-627)846650266 |0 (DE-576)454773552 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Trends in molecular medicine |d Amsterdam [u.a.] : Elsevier Science, 2001 |g 27(2021), 7, Seite 660-672 |h Online-Ressource |w (DE-627)391368036 |w (DE-600)2155736-6 |w (DE-576)252209338 |x 1471-499X |7 nnas |a Review alternative polyadenylation in stem cell self-renewal and differentiation |
| 773 | 1 | 8 | |g volume:27 |g year:2021 |g number:7 |g pages:660-672 |g extent:13 |a Review alternative polyadenylation in stem cell self-renewal and differentiation |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.molmed.2021.04.006 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2Fj.molmed.2021.04.006&DestApp=DOI&SrcAppSID=C2yaq1zUN4YUOwlDSEZ&SrcJTitle=TRENDS+IN+MOLECULAR+MEDICINE&DestDOIRegistrantName=Elsevier |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210910 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1081774134 |a Trumpp, Andreas |m 1081774134:Trumpp, Andreas |d 140000 |e 140000PT1081774134 |k 0/140000/ |p 3 |y j | ||
| 998 | |g 1191847837 |a Sommerkamp, Pia |m 1191847837:Sommerkamp, Pia |p 1 |x j | ||
| 999 | |a KXP-PPN1770007040 |e 397693254X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"extent":"13 S."}],"relHost":[{"part":{"volume":"27","text":"27(2021), 7, Seite 660-672","extent":"13","year":"2021","pages":"660-672","issue":"7"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 21.11.23"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Trends in molecular medicine","title_sort":"Trends in molecular medicine"}],"language":["eng"],"disp":"Review alternative polyadenylation in stem cell self-renewal and differentiationTrends in molecular medicine","recId":"391368036","id":{"issn":["1471-499X"],"eki":["391368036"],"zdb":["2155736-6"]},"pubHistory":["7.2001 -"],"origin":[{"dateIssuedKey":"2001","publisher":"Elsevier Science","dateIssuedDisp":"2001-","publisherPlace":"Amsterdam [u.a.]"}]}],"note":["Gesehen am 10.09.2021"],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"11 May 2021"}],"title":[{"title":"Review alternative polyadenylation in stem cell self-renewal and differentiation","title_sort":"Review alternative polyadenylation in stem cell self-renewal and differentiation"}],"person":[{"role":"aut","given":"Pia","roleDisplay":"VerfasserIn","display":"Sommerkamp, Pia","family":"Sommerkamp"},{"roleDisplay":"VerfasserIn","given":"Nina","display":"Cabezas Wallscheid, Nina","family":"Cabezas Wallscheid","role":"aut"},{"role":"aut","given":"Andreas","roleDisplay":"VerfasserIn","display":"Trumpp, Andreas","family":"Trumpp"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp"]},"recId":"1770007040","id":{"eki":["1770007040"],"doi":["10.1016/j.molmed.2021.04.006"]}} | ||
| SRT | |a SOMMERKAMPREVIEWALTE1120 | ||