Review alternative polyadenylation in stem cell self-renewal and differentiation
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 May 2021
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| In: |
Trends in molecular medicine
Year: 2021, Jahrgang: 27, Heft: 7, Pages: 660-672 |
| ISSN: | 1471-499X |
| DOI: | 10.1016/j.molmed.2021.04.006 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.molmed.2021.04.006 Verlag, lizenzpflichtig, Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2Fj.molmed.2021.04.006&DestApp=DOI&SrcAppSID=C2yaq1zUN4YUOwlDSEZ&SrcJTitle=TRENDS+IN+MOLECULAR+MEDICINE&DestDOIRegistrantName=Elsevier 
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| Verfasserangaben: | Pia Sommerkamp, Nina Cabezas-Wallscheid, and Andreas Trumpp |
MARC
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| 520 | |a Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3 '- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3 '-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3 '-UTRs, whereas proliferative stem/progenitor cells exhibit 3 '-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine. | ||
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