Physiological doses of calcium regulatory hormones do not normalize bone cells in uraemic rats
Low bone turnover despite normal parathyroid hormone (PTH) concentrations has been found in many patients with end-stage renal failure. Hyporesponsiveness to the calcaemic action is also a known feature of uraemia. Hyporesponsiveness of bone surface cells involved in bone modelling has not been demo...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1999
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| In: |
European journal of clinical investigation
Year: 1999, Volume: 29, Issue: 6, Pages: 529-535 |
| ISSN: | 1365-2362 |
| DOI: | 10.1046/j.1365-2362.1999.00499.x |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2362.1999.00499.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2362.1999.00499.x 
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| Author Notes: | A. Szabó, M.G. Freesmeyer, K. Abendroth, G. Stein, L. Rosivall, A. El-Shakmak and E. Ritz |
| Summary: | Low bone turnover despite normal parathyroid hormone (PTH) concentrations has been found in many patients with end-stage renal failure. Hyporesponsiveness to the calcaemic action is also a known feature of uraemia. Hyporesponsiveness of bone surface cells involved in bone modelling has not been demonstrated to date. It was the purpose of this study using a rat model of moderate renal failure to investigate whether doses of PTH and calcitriol that reverse the effect of parathyroidectomy on calcaemia also normalize bone surface cell activity. |
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| Item Description: | Der Verfasser A. Szabó ist aufgrund des fehlenden Vornamens und der Häufigkeit des Nachnamens nicht eindeutig identifizierbar Elektronische Reproduktion der Druck-Ausgabe, 24 December 2001 Gesehen am 15.09.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1365-2362 |
| DOI: | 10.1046/j.1365-2362.1999.00499.x |