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The role of ketogenesis in the migratory fattening of the northern wheatear Oenanthe oenanthe

The fuelling capacity of migratory birds and their ability to avoid health conditions derived from the subsequent fat overload are exceptional among vertebrates. In this work, we screen the expression of the genes involved in the production of ketone bodies (KB) in the liver of northern wheatears (O...

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Hauptverfasser: Frias Soler, Roberto Carlos (VerfasserIn) , Kelsey, Natalie A. (VerfasserIn) , Villarín Pildaín, Lilian (VerfasserIn) , Wink, Michael (VerfasserIn) , Bairlein, Franz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 July 2021
In: Biology letters
Year: 2021, Jahrgang: 17, Heft: 7, Pages: 1-6
ISSN:1744-957X
DOI:10.1098/rsbl.2021.0195
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1098/rsbl.2021.0195
Verlag, lizenzpflichtig, Volltext: https://royalsocietypublishing.org/doi/10.1098/rsbl.2021.0195
Volltext
Verfasserangaben:Roberto Carlos Frias-Soler, Natalie A. Kelsey, Lilian Villarín Pildaín, Michael Wink and Franz Bairlein
Beschreibung
Zusammenfassung:The fuelling capacity of migratory birds and their ability to avoid health conditions derived from the subsequent fat overload are exceptional among vertebrates. In this work, we screen the expression of the genes involved in the production of ketone bodies (KB) in the liver of northern wheatears (Oenanthe oenanthe) during the development and resolution of migratory fattening. Thirteen genes were found to be regulated among the migratory stages. Based on the dynamics of gene expression, we concluded that KB play a versatile role in wheatears' energy metabolism homeostasis. The ketogenic pathway can adaptively: (i) provide carbon equivalents for lipogenesis, speeding up fuelling; (ii) replace glucose during long-distance flights using lipids as the substrate; (iii) act as a floodgate to avoid steatosis; and (iv) might provide a metabolic solution to defatting in captive birds.
Beschreibung:Gesehen am 22.09.2021
Beschreibung:Online Resource
ISSN:1744-957X
DOI:10.1098/rsbl.2021.0195

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