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Co-morbidity but not dysglycaemia reduces quality of life in patients with type-2 diabetes treated with oral mono- or dual combination therapy: an analysis of the DiaRegis registry

Background: Type-2 diabetes mellitus has a major impact on health related quality of life (HRQoL). We aimed to identify patient and treatment related variables having a major impact. Methods: DiaRegis is a prospective diabetes registry. The EQ-5D was used to describe differences in HRQoL at baseline...

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Hauptverfasser: Wasem, Jürgen (VerfasserIn) , Bramlage, Peter (VerfasserIn) , Gitt, Anselm Kai (VerfasserIn) , Binz, Christiane (VerfasserIn) , Krekler, Michael (VerfasserIn) , Deeg, Evelin (VerfasserIn) , Tschöpe, Diethelm (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 March 2013
In: Cardiovascular diabetology
Year: 2013, Jahrgang: 12, Pages: 1-8
ISSN:1475-2840
DOI:10.1186/1475-2840-12-47
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2840-12-47
Volltext
Verfasserangaben:Jürgen Wasem, Peter Bramlage, Anselm K. Gitt, Christiane Binz, Michael Krekler, Evelin Deeg, Diethelm Tschöpe, for the DiaRegis Study Group
Beschreibung
Zusammenfassung:Background: Type-2 diabetes mellitus has a major impact on health related quality of life (HRQoL). We aimed to identify patient and treatment related variables having a major impact. Methods: DiaRegis is a prospective diabetes registry. The EQ-5D was used to describe differences in HRQoL at baseline. Odds ratios (OR) with 95% confidence intervals (CI) were determined from univariable regression analysis. For the identification of independent predictors of a low score on the EQ-5D, multivariable unconditional logistic regression analysis was performed. Results: A total of 2,760 patients were available for the present analysis (46.7% female, median age 66.2 years). Patients had considerable co-morbidity (18.3% coronary artery disease, 10.6% heart failure, 5.9% PAD and 5.0% stroke/TIA). Baseline HbA1c was 7.4%, fasting- and postprandial plasma glucose 139 mg/dl and 183 mg/dl. The median EQ-5D was 0.9 (interquartile range [IQR] 0.8–1.0). Independent predictors for a low EQ-5D were age > 66 years (OR 1.49; 95%CI 1.08–2.06), female gender (2.11; 1.55–2.86), hypertension (1.73; 1.03–2.93), peripheral neuropathy (1.62; 0.93–2.84) and clinically relevant depression (11.01; 3.97–30.50). There was no influence of dysglycaemia on the EQ-5D score. Conclusion: The present study suggests, that co-morbidity but not average glycaemic control reduces health related quality of life in type 2 diabetes mellitus.
Beschreibung:Gesehen am 30.09.2021
Beschreibung:Online Resource
ISSN:1475-2840
DOI:10.1186/1475-2840-12-47

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