Buchumschlag

Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism: results of a prospective multicenter study

To assess anxiety and depression symptoms, suicidal ideation, and health-related quality of life (HRQOL) in a large series of consecutive patients with primary hyperparathyroidism (pHPT) before and after parathyroidectomy.This prospective multicenter study investigated preoperative and postoperative...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Weber, Theresia (VerfasserIn) , Eberle, Julia (VerfasserIn) , Messelhäuser, Ursula (VerfasserIn) , Schiffmann, Leif (VerfasserIn) , Nies, Christoph (VerfasserIn) , Schabram, Jochen (VerfasserIn) , Zielke, Andreas (VerfasserIn) , Holzer, Katharina (VerfasserIn) , Rottler, Edit (VerfasserIn) , Henne-Bruns, Doris (VerfasserIn) , Keller, Monika (VerfasserIn) , Wietersheim, Jörn von (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2013
In: JAMA surgery
Year: 2013, Jahrgang: 148, Heft: 2, Pages: 109-115
ISSN:2168-6262
DOI:10.1001/2013.jamasurg.316
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1001/2013.jamasurg.316
Volltext
Verfasserangaben:Theresia Weber, Julia Eberle, Ursula Messelhäuser, Leif Schiffmann, Christoph Nies, Jochen Schabram, Andreas Zielke, Katharina Holzer, Edit Rottler, Doris Henne-Bruns, Monika Keller, Jörn von Wietersheim
Beschreibung
Zusammenfassung:To assess anxiety and depression symptoms, suicidal ideation, and health-related quality of life (HRQOL) in a large series of consecutive patients with primary hyperparathyroidism (pHPT) before and after parathyroidectomy.This prospective multicenter study investigated preoperative and postoperative depression, anxiety, suicidal ideation, and HRQOL in patients with pHPT and compared these variables with a control group with nontoxic thyroid nodules.The study included 194 patients with pHPT and 186 control subjects.Depression was evaluated with the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire-9, which also assessed suicidal ideation. Anxiety was evaluated with the HADS. Health-related quality of life was measured with the 36-Item Short Form survey.Parathyroidectomy achieved a 98% cure rate. Preoperatively, severe depression (HADS score ≥11) was seen in 20% of the pHPT group and 9% of the control group. The Patient Health Questionnaire-9 detected moderate to severe depression in 17% of the patients with pHPT and 7% of the control subjects. Patients with pHPT had higher HADS anxiety scores (mean, 7.7) than control subjects (P < .01) or the German normative sample (P < .001). Compared with control subjects, patients with pHPT had significantly lower 36-Item Short Form survey preoperative physical and mental health summary scores (42.7 vs 49.5 and 41.2 vs 46.8, respectively; P = .001 for both comparisons). At 12 months follow-up, depression and anxiety decreased significantly in patients with pHPT; the prevalence of suicidal ideation was more than halved from the baseline (10.7% vs 22%; P = .008). Both physical and mental health scores (45.7 and 47.7, respectively) improved in patients with pHPT (P < .001 each) but not in control subjects.Depression, anxiety, and decreased HRQOL appear to be related to pHPT. Successful parathyroidectomy seems to reduce psychopathologic symptoms and improve HRQOL in this setting.
Beschreibung:Published online October 15, 2012
Gesehen am 04.10.2021
Beschreibung:Online Resource
ISSN:2168-6262
DOI:10.1001/2013.jamasurg.316

Ähnliche Einträge