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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation, resulting in phosphorylation of the central NMD factor UPF1 and robust clearance of NMD targets via two seemingly indep...

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Hauptverfasser: Böhm, Volker (VerfasserIn) , Kückelmann, Sabrina (VerfasserIn) , Gerbracht, Jennifer V. (VerfasserIn) , Kallabis, Sebastian (VerfasserIn) , Britto-Borges, Thiago (VerfasserIn) , Altmüller, Janine (VerfasserIn) , Krüger, Marcus (VerfasserIn) , Dieterich, Christoph (VerfasserIn) , Gehring, Niels H. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 25 June 2021
In: Nature Communications
Year: 2021, Jahrgang: 12, Pages: 1-19
ISSN:2041-1723
DOI:10.1038/s41467-021-24046-3
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-24046-3
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-24046-3
Volltext
Verfasserangaben:Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich & Niels H. Gehring

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