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IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)

IMI2-PainCare-BioPain-RCT3 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on the nociceptive system that could serve to accelerate the future development of analgesics, by providing a quantitative understanding between drug expos...

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Main Authors: Mouraux, Andre (Author) , Bloms-Funke, Petra (Author) , Boesl, Irmgard (Author) , Caspani, Ombretta (Author) , Chapman, Sonya C. (Author) , Di Stefano, Giulia (Author) , Finnerup, Nanna Brix (Author) , Garcia-Larrea, Luis (Author) , Goetz, Marcus (Author) , Kostenko, Anna (Author) , Pelz, Bernhard (Author) , Pogatzki-Zahn, Esther (Author) , Schubart, Karin (Author) , Stouffs, Alexandre (Author) , Truini, Andrea (Author) , Tracey, Irene (Author) , Troconiz, Iñaki F. (Author) , Van Niel, Johannes (Author) , Vela, Jose Miguel (Author) , Vincent, Katy (Author) , Vollert, Jan (Author) , Wanigasekera, Vishvarani (Author) , Wittayer, Matthias Sebastian (Author) , Phillips, Keith G. (Author) , Treede, Rolf-Detlef (Author)
Format: Article (Journal)
Language:English
Published: 17 June 2021
In: Trials
Year: 2021, Volume: 22, Pages: 1-31
ISSN:1468-6694
DOI:10.1186/s13063-021-05272-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13063-021-05272-y
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Author Notes:André Mouraux, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Giulia Di Stefano, Nanna Brix Finnerup, Luis Garcia-Larrea, Marcus Goetz, Anna Kostenko, Bernhard Pelz, Esther Pogatzki-Zahn, Karin Schubart, Alexandre Stouffs, Andrea Truini, Irene Tracey, Iñaki F. Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer, Keith G. Phillips and Rolf-Detlef Treede
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Summary:IMI2-PainCare-BioPain-RCT3 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on the nociceptive system that could serve to accelerate the future development of analgesics, by providing a quantitative understanding between drug exposure and effects of the drug on nociceptive signal processing in human volunteers. IMI2-PainCare-BioPain-RCT3 will focus on biomarkers derived from non-invasive electroencephalographic (EEG) measures of brain activity.
Item Description:Gesehen am 13.10.2021
Physical Description:Online Resource
ISSN:1468-6694
DOI:10.1186/s13063-021-05272-y

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