Intravitreal 0.19 mg fluocinolone acetonide implant in non-infectious uveitis
The efficacy of the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN) in the treatment of non-infectious uveitic macular edema (UME) was assessed on twenty-six patients (34 eyes) with non-infectious UME between 2013 and 2020, in a mean follow-up of 18 ± 19.3 (mean ± SD) months. Mac...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 September 2021
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| In: |
Journal of Clinical Medicine
Year: 2021, Jahrgang: 10, Heft: 17, Pages: 1-14 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10173966 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm10173966 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/10/17/3966 
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| Verfasserangaben: | Muaas Hikal, Nil Celik, Gerd Uwe Auffarth, Lucy Joanne Kessler, Christian Steffen Mayer and Ramin Khoramnia |
| Zusammenfassung: | The efficacy of the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN) in the treatment of non-infectious uveitic macular edema (UME) was assessed on twenty-six patients (34 eyes) with non-infectious UME between 2013 and 2020, in a mean follow-up of 18 ± 19.3 (mean ± SD) months. Macular edema was resolved in 24 (70.6%) cases. Five of these eyes had a relapse after 23.2 ± 14 months. Three FAc reinjections were performed and a drying of the macula was observed. After FAc implantation, 24 eyes (70.6%) were completely dry; central retinal thickness (CRT) decreased in 6 eyes (17.6%), but residual intraretinal fluid was still evident. In 20 eyes (58.5%), visual acuity (VA) improved (from +1 to +5 lines) and remained stable in 9 eyes (26.5%). Thirty eyes (88.2%) were pseudophakic at baseline and four were phakic. Three of these eyes had a cataract prior to therapy and the other developed a cataract 2.5 years after the FAc implant was administered. There was an overall increase in intraocular pressure (IOP; +4.4 ± 3.7 mmHg) and eye drops were required in three eyes. The FAc implant led to long-term improvements in mean CRT and VA, and that the side-effect profile was manageable in a clinical setting in patients with non-infectious UME. |
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| Beschreibung: | Gesehen am 18.10.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10173966 |