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Intravitreal 0.19 mg fluocinolone acetonide implant in non-infectious uveitis

The efficacy of the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN) in the treatment of non-infectious uveitic macular edema (UME) was assessed on twenty-six patients (34 eyes) with non-infectious UME between 2013 and 2020, in a mean follow-up of 18 ± 19.3 (mean ± SD) months. Mac...

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Main Authors: Hikal, Muaas (Author) , Celik, Nil (Author) , Auffarth, Gerd U. (Author) , Kessler, Lucy Joanne (Author) , Mayer, Christian (Author) , Khoramnia, Ramin (Author)
Format: Article (Journal)
Language:English
Published: 1 September 2021
In: Journal of Clinical Medicine
Year: 2021, Volume: 10, Issue: 17, Pages: 1-14
ISSN:2077-0383
DOI:10.3390/jcm10173966
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm10173966
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/10/17/3966
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Author Notes:Muaas Hikal, Nil Celik, Gerd Uwe Auffarth, Lucy Joanne Kessler, Christian Steffen Mayer and Ramin Khoramnia

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520 |a The efficacy of the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN) in the treatment of non-infectious uveitic macular edema (UME) was assessed on twenty-six patients (34 eyes) with non-infectious UME between 2013 and 2020, in a mean follow-up of 18 ± 19.3 (mean ± SD) months. Macular edema was resolved in 24 (70.6%) cases. Five of these eyes had a relapse after 23.2 ± 14 months. Three FAc reinjections were performed and a drying of the macula was observed. After FAc implantation, 24 eyes (70.6%) were completely dry; central retinal thickness (CRT) decreased in 6 eyes (17.6%), but residual intraretinal fluid was still evident. In 20 eyes (58.5%), visual acuity (VA) improved (from +1 to +5 lines) and remained stable in 9 eyes (26.5%). Thirty eyes (88.2%) were pseudophakic at baseline and four were phakic. Three of these eyes had a cataract prior to therapy and the other developed a cataract 2.5 years after the FAc implant was administered. There was an overall increase in intraocular pressure (IOP; +4.4 ± 3.7 mmHg) and eye drops were required in three eyes. The FAc implant led to long-term improvements in mean CRT and VA, and that the side-effect profile was manageable in a clinical setting in patients with non-infectious UME. 
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